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GNG4

GENERAL INFORMATION

Gene name

 GNG4

Gene description

 Guanine nucleotide binding protein (G protein), gamma 4

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex, ovary, prostate)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GNG4

Synonyms

Description

 Guanine nucleotide binding protein (G protein), gamma 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q42.3

Chromosome location (bp)

 235547687 - 235650754

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168243 (version 83.38)

Entrez gene

 2786

UniProt

 P50150 (UniProt - Evidence at protein level)

neXtProt

 NX_P50150

Antibodypedia

 GNG4 antibodies

PROTEIN BROWSER
GNG4-001
GNG4-002
GNG4-003
GNG4-201
GNG4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG4-001
ENSP00000355557
ENST00000366598
P50150 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
B1APZ0 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 75 aa
8.4 kDa 		No 0
GNG4-002
ENSP00000355556
ENST00000366597
P50150 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
B1APZ0 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 75 aa
8.4 kDa 		No 0
GNG4-003
ENSP00000482192
ENST00000484517
P50150 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
B1APZ0 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 75 aa
8.4 kDa 		No 0
GNG4-201
ENSP00000375727
ENST00000391854
P50150 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
B1APZ0 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 75 aa
8.4 kDa 		No 0
GNG4-202
ENSP00000398629
ENST00000450593
P50150 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
B1APZ0 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 75 aa
8.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.