Expression of KIF5C in cancer - Summary

GENERAL INFORMATION
Gene name	KIF5C
Gene description	Kinesin family member 5C
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including brain and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035210
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035210

GENE INFORMATION
Gene name	KIF5C
Synonyms
Description	Kinesin family member 5C (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
Chromosome	2
Cytoband
Chromosome location (bp)	148875250 - 149026759
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168280 (version 83.38)
Entrez gene	3800
UniProt	O60282 (UniProt - Evidence at protein level)
neXtProt	NX_O60282
Antibodypedia	KIF5C antibodies

PROTEIN BROWSER

KIF5C-001	KIF5C-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIF5C-001 ENSP00000393379 ENST00000435030	O60282 [Direct mapping] Kinesin heavy chain isoform 5C Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0006996 [organelle organization] GO:0007018 [microtubule-based movement] GO:0007411 [axon guidance] GO:0008017 [microtubule binding] GO:0008104 [protein localization] GO:0008152 [metabolic process] GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed] GO:0030705 [cytoskeleton-dependent intracellular transport] GO:0034190 [apolipoprotein receptor binding] GO:0051028 [mRNA transport] Show all	957 aa 109.5 kDa	No	0
KIF5C-005 ENSP00000393270 ENST00000450621	C9JWB9 [Direct mapping] Kinesin heavy chain isoform 5C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0007411 [axon guidance] GO:0008017 [microtubule binding] GO:0008104 [protein localization] GO:0008152 [metabolic process] GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed] GO:0030705 [cytoskeleton-dependent intracellular transport] Show all	76 aa 8.7 kDa	No	0