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KIF5C

GENERAL INFORMATION

Gene name

 KIF5C

Gene description

 Kinesin family member 5C

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex, hippocampus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, including brain and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035210
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, testis)

GENE INFORMATION

Gene name

 KIF5C

Synonyms

Description

 Kinesin family member 5C (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 2

Cytoband

Chromosome location (bp)

 148875250 - 149026759

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168280 (version 83.38)

Entrez gene

 3800

UniProt

 O60282 (UniProt - Evidence at protein level)

neXtProt

 NX_O60282

Antibodypedia

 KIF5C antibodies

PROTEIN BROWSER
KIF5C-001
KIF5C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF5C-001
ENSP00000393379
ENST00000435030
O60282 [Direct mapping]
Kinesin heavy chain isoform 5C
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0034190 [apolipoprotein receptor binding]
GO:0051028 [mRNA transport]
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 957 aa
109.5 kDa 		No 0
KIF5C-005
ENSP00000393270
ENST00000450621
C9JWB9 [Direct mapping]
Kinesin heavy chain isoform 5C
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
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 76 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.