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PDHB

GENERAL INFORMATION

Gene name

 PDHB

Gene description

 Pyruvate dehydrogenase (lipoamide) beta

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA036744 , HPA036745 , CAB033794
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA036744
HPA036745
CAB033794

GENE INFORMATION

Gene name

 PDHB

Synonyms

Description

 Pyruvate dehydrogenase (lipoamide) beta (HGNC Symbol)

Entrez gene summary

 The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 3

Cytoband

 p14.3

Chromosome location (bp)

 58427630 - 58433857

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168291 (version 83.38)

Entrez gene

 5162

UniProt

 P11177 (UniProt - Evidence at protein level)

neXtProt

 NX_P11177

Antibodypedia

 PDHB antibodies

PROTEIN BROWSER
PDHB-001
PDHB-005
PDHB-007
PDHB-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDHB-001
ENSP00000307241
ENST00000302746
P11177 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0034604 [pyruvate dehydrogenase (NAD+) activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
GO:0061732 [mitochondrial acetyl-CoA biosynthetic process from pyruvate]
GO:0070062 [extracellular exosome]
Show all
 359 aa
39.2 kDa 		No 0
PDHB-005
ENSP00000417267
ENST00000485460
P11177 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0034604 [pyruvate dehydrogenase (NAD+) activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
GO:0061732 [mitochondrial acetyl-CoA biosynthetic process from pyruvate]
GO:0070062 [extracellular exosome]
Show all
 341 aa
37.5 kDa 		No 0
PDHB-007
ENSP00000418448
ENST00000474765
C9J634 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0008152 [metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 350 aa
38.4 kDa 		No 0
PDHB-008
ENSP00000373220
ENST00000383714
P11177 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0034604 [pyruvate dehydrogenase (NAD+) activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
GO:0061732 [mitochondrial acetyl-CoA biosynthetic process from pyruvate]
GO:0070062 [extracellular exosome]
Show all
 341 aa
37.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.