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ACOX2

GENERAL INFORMATION

Gene name

 ACOX2

Gene description

 Acyl-CoA oxidase 2, branched chain

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enhanced (ASC TERT1, BEWO, Hep G2)
HPA (normal tissue):Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA038280
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038280

GENE INFORMATION

Gene name

 ACOX2 (HGNC Symbol)

Synonyms

 BRCACOX, BRCOX, THCCox

Description

 Acyl-CoA oxidase 2, branched chain (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]

Chromosome

 3

Cytoband

 p14.3

Chromosome location (bp)

 58505136 - 58537319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168306 (version 83.38)

Entrez gene

 8309

UniProt

 Q99424 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99424

Antibodypedia

 ACOX2 antibodies

PROTEIN BROWSER
ACOX2-001
ACOX2-002
ACOX2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOX2-001
ENSP00000307697
ENST00000302819
Q99424 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005504 [fatty acid binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006699 [bile acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0009055 [electron carrier activity]
GO:0016402 [pristanoyl-CoA oxidase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033791 [3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
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 681 aa
76.8 kDa 		No 0
ACOX2-002
ENSP00000418562
ENST00000459701
C9J0G0 [Direct mapping]
Acyl-coenzyme A oxidase
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005777 [peroxisome]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 667 aa
75.1 kDa 		No 0
ACOX2-004
ENSP00000419927
ENST00000474098
C9JY29 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 171 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.