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ING5

GENERAL INFORMATION

Gene name

 ING5

Gene description

 Inhibitor of growth family, member 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042685
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042685

GENE INFORMATION

Gene name

 ING5 (HGNC Symbol)

Synonyms

 FLJ23842, p28ING5

Description

 Inhibitor of growth family, member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241702035 - 241729478

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168395 (version 83.38)

Entrez gene

 84289

UniProt

 Q8WYH8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYH8

Antibodypedia

 ING5 antibodies

PROTEIN BROWSER
ING5-001
ING5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ING5-001
ENSP00000322142
ENST00000313552
Q8WYH8 [Direct mapping]
Inhibitor of growth protein 5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
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 240 aa
27.8 kDa 		No 0
ING5-002
ENSP00000385937
ENST00000406941
Q8WYH8 [Direct mapping]
Inhibitor of growth protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 226 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.