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ING5

GENERAL INFORMATION

Gene name

 ING5

Gene description

 Inhibitor of growth family, member 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042685
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ING5 (HGNC Symbol)

Synonyms

 FLJ23842, p28ING5

Description

 Inhibitor of growth family, member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241702035 - 241729478

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168395 (version 83.38)

Entrez gene

 84289

UniProt

 Q8WYH8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYH8

Antibodypedia

 ING5 antibodies

PROTEIN BROWSER
ING5-001
ING5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ING5-001
ENSP00000322142
ENST00000313552
Q8WYH8 [Direct mapping]
Inhibitor of growth protein 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 240 aa
27.8 kDa 		No 0
ING5-002
ENSP00000385937
ENST00000406941
Q8WYH8 [Direct mapping]
Inhibitor of growth protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0035064 [methylated histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045926 [negative regulation of growth]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 226 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.