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MTNR1A

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GENERAL INFORMATION

Gene name

 MTNR1A

Gene description

 Melatonin receptor 1A

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MTNR1A (HGNC Symbol)

Synonyms

 MEL-1A-R

Description

 Melatonin receptor 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q35.2

Chromosome location (bp)

 186533655 - 186555567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168412 (version 83.38)

Entrez gene

 4543

UniProt

 P48039 (UniProt - Evidence at protein level)

neXtProt

 NX_P48039

Antibodypedia

 MTNR1A antibodies

PROTEIN BROWSER
MTNR1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTNR1A-001
ENSP00000302811
ENST00000307161
P48039 [Direct mapping]
Melatonin receptor type 1A
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007568 [aging]
GO:0007617 [mating behavior]
GO:0007623 [circadian rhythm]
GO:0008502 [melatonin receptor activity]
GO:0016021 [integral component of membrane]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0042562 [hormone binding]
GO:0043010 [camera-type eye development]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0046676 [negative regulation of insulin secretion]
GO:0097159 [organic cyclic compound binding]
Show all
 350 aa
39.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.