Tissue expression of MTNR1A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MTNR1A
Gene description	Melatonin receptor 1A
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney, testis)
GTEx:	Tissue enhanced (cerebellum, kidney, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, kidney, testis)

GENE INFORMATION
Gene name	MTNR1A (HGNC Symbol)
Synonyms	MEL-1A-R
Description	Melatonin receptor 1A (HGNC Symbol)
Entrez gene summary	This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q35.2
Chromosome location (bp)	186533655 - 186555567
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168412 (version 83.38)
Entrez gene	4543
UniProt	P48039 (UniProt - Evidence at protein level)
neXtProt	NX_P48039
Antibodypedia	MTNR1A antibodies

PROTEIN BROWSER

MTNR1A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTNR1A-001 ENSP00000302811 ENST00000307161	P48039 [Direct mapping] Melatonin receptor type 1A Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007568 [aging] GO:0007617 [mating behavior] GO:0007623 [circadian rhythm] GO:0008502 [melatonin receptor activity] GO:0016021 [integral component of membrane] GO:0030828 [positive regulation of cGMP biosynthetic process] GO:0042562 [hormone binding] GO:0043010 [camera-type eye development] GO:0043025 [neuronal cell body] GO:0043235 [receptor complex] GO:0046676 [negative regulation of insulin secretion] GO:0097159 [organic cyclic compound binding] Show all	350 aa 39.4 kDa	No	7