Tissue expression of STIP1 - Summary - The Human Protein Atlas

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STIP1

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	STIP1
Gene description	Stress-induced phosphoprotein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA039291 , HPA044062 , CAB017448
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	STIP1 (HGNC Symbol)
Synonyms	HOP, STI1
Description	Stress-induced phosphoprotein 1 (HGNC Symbol)
Entrez gene summary	STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64185272 - 64204543
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168439 (version 83.38)
Entrez gene	10963
UniProt	P31948 (UniProt - Evidence at protein level)
neXtProt	NX_P31948
Antibodypedia	STIP1 antibodies

PROTEIN BROWSER

STIP1-001	STIP1-003	STIP1-008	STIP1-010	STIP1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STIP1-001 ENSP00000305958 ENST00000305218	P31948 [Direct mapping] Stress-induced-phosphoprotein 1 V9HW72 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 94n; Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein), isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006950 [response to stress] GO:0044822 [poly(A) RNA binding] Show all	543 aa 62.6 kDa	No	0
STIP1-003 ENSP00000445957 ENST00000538945	P31948 [Direct mapping] Stress-induced-phosphoprotein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006950 [response to stress] GO:0044822 [poly(A) RNA binding] Show all	519 aa 59.8 kDa	No	0
STIP1-008 ENSP00000443416 ENST00000540887	H0YGI8 [Direct mapping] Stress-induced-phosphoprotein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	137 aa 16 kDa	No	0
STIP1-010 ENSP00000351646 ENST00000358794	P31948 [Direct mapping] Stress-induced-phosphoprotein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006950 [response to stress] GO:0008022 [protein C-terminus binding] GO:0030544 [Hsp70 protein binding] GO:0043209 [myelin sheath] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] GO:0051087 [chaperone binding] Show all	590 aa 68.1 kDa	No	0
STIP1-012 ENSP00000442704 ENST00000543847	F5H783 [Direct mapping] Stress-induced-phosphoprotein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	236 aa 27 kDa	No	0

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