Cell atlas - ATXN2L - The Human Protein Atlas

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ATXN2L

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ATXN2L
Gene description	Ataxin 2-like
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA041506 , HPA043391 , HPA071955
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA041506	A-431	Cytosol
HPA041506	U-2 OS	Cytosol
HPA041506	U-251 MG	Cytosol
HPA043391	A-431	Cytosol
HPA043391	U-2 OS	Cytosol
HPA043391	U-251 MG	Cytosol
HPA071955	HaCaT	Cytosol
HPA071955	Hep G2	Cytosol
HPA071955	U-2 OS	Cytosol

siRNA VALIDATION

Antibody

HPA041506

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

44%

31%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA041506	siRNA 2	U-2 OS
HPA041506	scrambled	U-2 OS
HPA041506	siRNA 1	U-2 OS

GENE INFORMATION
Gene name	ATXN2L (HGNC Symbol)
Synonyms	A2D, A2lp
Description	Ataxin 2-like (HGNC Symbol)
Entrez gene summary	This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28823035 - 28837237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168488 (version 83.38)
Entrez gene	11273
UniProt	Q8WWM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWM7
Antibodypedia	ATXN2L antibodies

PROTEIN BROWSER

ATXN2L-001	ATXN2L-002	ATXN2L-003	ATXN2L-004	ATXN2L-005	ATXN2L-006	ATXN2L-008	ATXN2L-011	ATXN2L-013	ATXN2L-016	ATXN2L-017	ATXN2L-024	ATXN2L-026	ATXN2L-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATXN2L-001 ENSP00000341459 ENST00000340394	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.3 kDa	No	0
ATXN2L-002 ENSP00000378917 ENST00000395547	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1097 aa 115.6 kDa	No	0
ATXN2L-003 ENSP00000338718 ENST00000336783	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1075 aa 113.4 kDa	No	0
ATXN2L-004 ENSP00000372133 ENST00000382686	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.1 kDa	No	0
ATXN2L-005 ENSP00000315650 ENST00000325215	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 111.9 kDa	No	0
ATXN2L-006 ENSP00000454516 ENST00000570200	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 112.1 kDa	No	0
ATXN2L-008 ENSP00000457613 ENST00000564304	H3BUF6 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	1068 aa 112.7 kDa	No	0
ATXN2L-011 ENSP00000454757 ENST00000566946	A0A0C4DGL7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		401 aa 41.8 kDa	No	0
ATXN2L-013 ENSP00000456752 ENST00000568266	H3BSK9 [Direct mapping] Ataxin-2-like protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		336 aa 37.1 kDa	No	0
ATXN2L-016 ENSP00000456812 ENST00000564656	H3BSQ5 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.1 kDa	No	0
ATXN2L-017 ENSP00000455981 ENST00000566007	H3BQX7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13 kDa	No	0
ATXN2L-024 ENSP00000454588 ENST00000569318	H3BMX1 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 19.1 kDa	No	0
ATXN2L-026 ENSP00000455560 ENST00000567024	H3BQ14 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		11 aa 1 kDa	No	0
ATXN2L-027 ENSP00000455427 ENST00000564162	H3BPQ7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.