Expression of ATXN2L in cancer - Summary

GENERAL INFORMATION
Gene name	ATXN2L
Gene description	Ataxin 2-like
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including a few cases of membrane expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA041506 , HPA043391
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041506	HPA043391

GENE INFORMATION
Gene name	ATXN2L (HGNC Symbol)
Synonyms	A2D, A2lp
Description	Ataxin 2-like (HGNC Symbol)
Entrez gene summary	This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28823035 - 28837237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168488 (version 83.38)
Entrez gene	11273
UniProt	Q8WWM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWM7
Antibodypedia	ATXN2L antibodies

PROTEIN BROWSER

ATXN2L-001	ATXN2L-002	ATXN2L-003	ATXN2L-004	ATXN2L-005	ATXN2L-006	ATXN2L-008	ATXN2L-011	ATXN2L-013	ATXN2L-016	ATXN2L-017	ATXN2L-024	ATXN2L-026	ATXN2L-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATXN2L-001 ENSP00000341459 ENST00000340394	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.3 kDa	No	0
ATXN2L-002 ENSP00000378917 ENST00000395547	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1097 aa 115.6 kDa	No	0
ATXN2L-003 ENSP00000338718 ENST00000336783	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1075 aa 113.4 kDa	No	0
ATXN2L-004 ENSP00000372133 ENST00000382686	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.1 kDa	No	0
ATXN2L-005 ENSP00000315650 ENST00000325215	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 111.9 kDa	No	0
ATXN2L-006 ENSP00000454516 ENST00000570200	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 112.1 kDa	No	0
ATXN2L-008 ENSP00000457613 ENST00000564304	H3BUF6 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	1068 aa 112.7 kDa	No	0
ATXN2L-011 ENSP00000454757 ENST00000566946	A0A0C4DGL7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		401 aa 41.8 kDa	No	0
ATXN2L-013 ENSP00000456752 ENST00000568266	H3BSK9 [Direct mapping] Ataxin-2-like protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		336 aa 37.1 kDa	No	0
ATXN2L-016 ENSP00000456812 ENST00000564656	H3BSQ5 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.1 kDa	No	0
ATXN2L-017 ENSP00000455981 ENST00000566007	H3BQX7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13 kDa	No	0
ATXN2L-024 ENSP00000454588 ENST00000569318	H3BMX1 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 19.1 kDa	No	0
ATXN2L-026 ENSP00000455560 ENST00000567024	H3BQ14 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		11 aa 1 kDa	No	0
ATXN2L-027 ENSP00000455427 ENST00000564162	H3BPQ7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.3 kDa	No	0