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MTCL1

GENERAL INFORMATION

Gene name

 MTCL1

Gene description

 Microtubule crosslinking factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA046245
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA046245

GENE INFORMATION

Gene name

 MTCL1 (HGNC Symbol)

Synonyms

 CCDC165, KIAA0802, SOGA2

Description

 Microtubule crosslinking factor 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 p11.22

Chromosome location (bp)

 8705661 - 8832778

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168502 (version 83.38)

Entrez gene

 23255

UniProt

 Q9Y4B5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4B5

Antibodypedia

 MTCL1 antibodies

PROTEIN BROWSER
MTCL1-001
MTCL1-003
MTCL1-006
MTCL1-007
MTCL1-015
MTCL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTCL1-001
ENSP00000352927
ENST00000359865
Q9Y4B5 [Direct mapping]
Microtubule cross-linking factor 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008017 [microtubule binding]
GO:0010506 [regulation of autophagy]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0030496 [midbody]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097427 [microtubule bundle]
GO:2000576 [positive regulation of microtubule motor activity]
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 1586 aa
177.9 kDa 		No 0
MTCL1-003
ENSP00000429556
ENST00000517570
Q9Y4B5 [Direct mapping]
Microtubule cross-linking factor 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008017 [microtubule binding]
GO:0010506 [regulation of autophagy]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0030496 [midbody]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097427 [microtubule bundle]
GO:2000576 [positive regulation of microtubule motor activity]
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 1545 aa
173.3 kDa 		No 0
MTCL1-006
ENSP00000463465
ENST00000518815
Q9Y4B5 [Direct mapping]
Microtubule cross-linking factor 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008017 [microtubule binding]
GO:0010506 [regulation of autophagy]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0030496 [midbody]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097427 [microtubule bundle]
GO:2000576 [positive regulation of microtubule motor activity]
Show all
 976 aa
108.7 kDa 		No 0
MTCL1-007
ENSP00000463506
ENST00000523122
J3QLE1 [Direct mapping]
Microtubule cross-linking factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0097427 [microtubule bundle]
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 47 aa
5.9 kDa 		No 0
MTCL1-015
ENSP00000305027
ENST00000306329
Q9Y4B5 [Direct mapping]
Microtubule cross-linking factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008017 [microtubule binding]
GO:0010506 [regulation of autophagy]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0030496 [midbody]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097427 [microtubule bundle]
GO:2000576 [positive regulation of microtubule motor activity]
Show all
 1905 aa
209.5 kDa 		No 0
MTCL1-201
ENSP00000382924
ENST00000400050
Q9Y4B5 [Direct mapping]
Microtubule cross-linking factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008017 [microtubule binding]
GO:0010506 [regulation of autophagy]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0030496 [midbody]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097427 [microtubule bundle]
GO:2000576 [positive regulation of microtubule motor activity]
Show all
 1586 aa
177.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.