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COL3A1

GENERAL INFORMATION

Gene name

 COL3A1

Gene description

 Collagen, type III, alpha 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, gallbladder, smooth muscle)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cervix, uterine, endometrium)

Protein evidence

 Evidence at protein level

Protein expression

 Secreted and extracellular positivity in most tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 3 antibodies.
HPA007583 , CAB016766 , CAB059993
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, gallbladder, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, endometrium)

GENE INFORMATION

Gene name

 COL3A1 (HGNC Symbol)

Synonyms

 EDS4A

Description

 Collagen, type III, alpha 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Chromosome

 2

Cytoband

 q32.2

Chromosome location (bp)

 188974320 - 189012746

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168542 (version 83.38)

Entrez gene

 1281

UniProt

 P02461 (UniProt - Evidence at protein level)

neXtProt

 NX_P02461

Antibodypedia

 COL3A1 antibodies

PROTEIN BROWSER
COL3A1-001
COL3A1-004
COL3A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL3A1-001
ENSP00000304408
ENST00000304636
P02461 [Direct mapping]
Collagen alpha-1(III) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001568 [blood vessel development]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005586 [collagen type III trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006898 [receptor-mediated endocytosis]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0009314 [response to radiation]
GO:0009612 [response to mechanical stimulus]
GO:0018149 [peptide cross-linking]
GO:0021987 [cerebral cortex development]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0034097 [response to cytokine]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042060 [wound healing]
GO:0043206 [extracellular fibril organization]
GO:0043588 [skin development]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048407 [platelet-derived growth factor binding]
GO:0048565 [digestive tract development]
GO:0050776 [regulation of immune response]
GO:0050777 [negative regulation of immune response]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0071230 [cellular response to amino acid stimulus]
GO:2001223 [negative regulation of neuron migration]
Show all
 1466 aa
138.6 kDa 		Yes 0
COL3A1-004
ENSP00000415346
ENST00000450867
H7C435 [Direct mapping]
Collagen alpha-1(III) chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 90 aa
7.9 kDa 		No 0
COL3A1-201
ENSP00000315243
ENST00000317840
P02461 [Direct mapping]
Collagen alpha-1(III) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005586 [collagen type III trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006898 [receptor-mediated endocytosis]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0009314 [response to radiation]
GO:0018149 [peptide cross-linking]
GO:0021987 [cerebral cortex development]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0034097 [response to cytokine]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042060 [wound healing]
GO:0043206 [extracellular fibril organization]
GO:0043588 [skin development]
GO:0046872 [metal ion binding]
GO:0048407 [platelet-derived growth factor binding]
GO:0050776 [regulation of immune response]
GO:0050777 [negative regulation of immune response]
GO:2001223 [negative regulation of neuron migration]
Show all
 1163 aa
111.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.