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CDKN2AIP

GENERAL INFORMATION

Gene name

 CDKN2AIP

Gene description

 CDKN2A interacting protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA041397
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041397

GENE INFORMATION

Gene name

 CDKN2AIP (HGNC Symbol)

Synonyms

 CARF, FLJ20036

Description

 CDKN2A interacting protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 4

Cytoband

 q35.1

Chromosome location (bp)

 183444591 - 183448198

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168564 (version 83.38)

Entrez gene

 55602

UniProt

 Q9NXV6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NXV6

Antibodypedia

 CDKN2AIP antibodies

PROTEIN BROWSER
CDKN2AIP-001
CDKN2AIP-002
CDKN2AIP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKN2AIP-001
ENSP00000427108
ENST00000504169
Q9NXV6 [Direct mapping]
CDKN2A-interacting protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001652 [granular component]
GO:0002039 [p53 binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009967 [positive regulation of signal transduction]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031647 [regulation of protein stability]
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 580 aa
61.1 kDa 		No 0
CDKN2AIP-002
ENSP00000303788
ENST00000302350
J3KNE1 [Direct mapping]
CDKN2A-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 126 aa
14 kDa 		No 0
CDKN2AIP-004
ENSP00000421308
ENST00000510928
D6RGD2 [Direct mapping]
CDKN2A-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.