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STAT3

GENERAL INFORMATION

Gene name

 STAT3

Gene description

 Signal transducer and activator of transcription 3 (acute-phase response factor)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA001671 , HPA058603 , CAB003859 , CAB068241 , CAB068242
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA001671
HPA058603
CAB003859
CAB068241
CAB068242

GENE INFORMATION

Gene name

 STAT3 (HGNC Symbol)

Synonyms

 APRF

Description

 Signal transducer and activator of transcription 3 (acute-phase response factor) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42313324 - 42388568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168610 (version 83.38)

Entrez gene

 6774

UniProt

 P40763 (UniProt - Evidence at protein level)

neXtProt

 NX_P40763

Antibodypedia

 STAT3 antibodies

PROTEIN BROWSER
STAT3-001
STAT3-002
STAT3-011
STAT3-012
STAT3-013
STAT3-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT3-001
ENSP00000264657
ENST00000264657
P40763 [Direct mapping]
Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001659 [temperature homeostasis]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0006928 [movement of cell or subcellular component]
GO:0006953 [acute-phase response]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007399 [nervous system development]
GO:0007568 [aging]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010033 [response to organic substance]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014070 [response to organic cyclic compound]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019827 [stem cell population maintenance]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019953 [sexual reproduction]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0034097 [response to cytokine]
GO:0035019 [somatic stem cell population maintenance]
GO:0035259 [glucocorticoid receptor binding]
GO:0040014 [regulation of multicellular organism growth]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0043434 [response to peptide hormone]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045471 [response to ethanol]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045820 [negative regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046983 [protein dimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048708 [astrocyte differentiation]
GO:0060019 [radial glial cell differentiation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0060548 [negative regulation of cell death]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1901215 [negative regulation of neuron death]
GO:1902728 [positive regulation of growth factor dependent skeletal muscle satellite cell proliferation]
GO:2001171 [positive regulation of ATP biosynthetic process]
GO:2001223 [negative regulation of neuron migration]
Show all
 770 aa
88.1 kDa 		No 0
STAT3-002
ENSP00000384943
ENST00000404395
P40763 [Direct mapping]
Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001659 [temperature homeostasis]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019953 [sexual reproduction]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035019 [somatic stem cell population maintenance]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048708 [astrocyte differentiation]
GO:0060019 [radial glial cell differentiation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 769 aa
88 kDa 		No 0
STAT3-011
ENSP00000467985
ENST00000588969
P40763 [Direct mapping]
Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001659 [temperature homeostasis]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019953 [sexual reproduction]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035019 [somatic stem cell population maintenance]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048708 [astrocyte differentiation]
GO:0060019 [radial glial cell differentiation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 770 aa
88.1 kDa 		No 0
STAT3-012
ENSP00000467000
ENST00000585517
P40763 [Direct mapping]
Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001659 [temperature homeostasis]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019953 [sexual reproduction]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035019 [somatic stem cell population maintenance]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048708 [astrocyte differentiation]
GO:0060019 [radial glial cell differentiation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 722 aa
83.1 kDa 		No 0
STAT3-013
ENSP00000373923
ENST00000389272
G8JLH9 [Direct mapping]
Signal transducer and activator of transcription
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 672 aa
76.1 kDa 		No 0
STAT3-016
ENSP00000467173
ENST00000588065
K7EP08 [Direct mapping]
Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 84 aa
10.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.