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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AXIN2
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AXIN2

Gene description

Axin 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, CACO-2, Hep G2)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
CAB012283 , CAB017783
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB012283
CAB017783

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic and nuclear immunoreactivity. A few cases of melanomas, colorectal and liver cancers were strongly positive.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic and nuclear staining was observed in most cancer tissues. A majority of gliomas showed strong nuclear staining while squamous cell carcinomas in skin were weakly stained.

GENE INFORMATION

Gene name

AXIN2 (HGNC Symbol)

Synonyms

DKFZp781B0869, MGC126582

Description

Axin 2 (HGNC Symbol)

Entrez gene summary

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.1

Chromosome location (bp)

65528563 - 65561647

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168646 (version 83.38)

Entrez gene

8313

UniProt

Q9Y2T1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2T1

Antibodypedia

AXIN2 antibodies

PROTEIN BROWSER

AXIN2-001
AXIN2-004
AXIN2-005
AXIN2-006
AXIN2-007
AXIN2-008
AXIN2-201
AXIN2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXIN2-001
ENSP00000302625
ENST00000307078
Q9Y2T1 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001957 [intramembranous ossification]
GO:0003139 [secondary heart field specification]
GO:0003413 [chondrocyte differentiation involved in endochondral bone morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009950 [dorsal/ventral axis specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010942 [positive regulation of cell death]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030154 [cell differentiation]
GO:0030282 [bone mineralization]
GO:0030877 [beta-catenin destruction complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032423 [regulation of mismatch repair]
GO:0034613 [cellular protein localization]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0042476 [odontogenesis]
GO:0043547 [positive regulation of GTPase activity]
GO:0043570 [maintenance of DNA repeat elements]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0048255 [mRNA stabilization]
GO:0061181 [regulation of chondrocyte development]
GO:0070016 [armadillo repeat domain binding]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
843 aa
93.6 kDa
No 0
AXIN2-004
ENSP00000364854
ENST00000375702
E7ES00 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
778 aa
86.7 kDa
No 0
AXIN2-005
ENSP00000463761
ENST00000580513
J3QQJ3 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
192 aa
21.6 kDa
Yes 0
AXIN2-006
ENSP00000464264
ENST00000577278
J3QRK4 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
271 aa
30.1 kDa
No 0
AXIN2-007
ENSP00000463192
ENST00000585045
J3QQJ3 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
192 aa
21.6 kDa
Yes 0
AXIN2-008
ENSP00000441151
ENST00000544103
F5GX43 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
151 aa
16.8 kDa
Yes 0
AXIN2-201
ENSP00000481191
ENST00000611991
A0A087WXP8 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
160 aa
18 kDa
Yes 0
AXIN2-202
ENSP00000478916
ENST00000618960
E7ES00 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
778 aa
86.7 kDa
No 0

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