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AXIN2

GENERAL INFORMATION

Gene name

 AXIN2

Gene description

 Axin 2

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, CACO-2, Hep G2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
CAB012283 , CAB017783
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012283
CAB017783

GENE INFORMATION

Gene name

 AXIN2 (HGNC Symbol)

Synonyms

 DKFZp781B0869, MGC126582

Description

 Axin 2 (HGNC Symbol)

Entrez gene summary

 The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q24.1

Chromosome location (bp)

 65528563 - 65561647

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168646 (version 83.38)

Entrez gene

 8313

UniProt

 Q9Y2T1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2T1

Antibodypedia

 AXIN2 antibodies

PROTEIN BROWSER
AXIN2-001
AXIN2-004
AXIN2-005
AXIN2-006
AXIN2-007
AXIN2-008
AXIN2-201
AXIN2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AXIN2-001
ENSP00000302625
ENST00000307078
Q9Y2T1 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001957 [intramembranous ossification]
GO:0003139 [secondary heart field specification]
GO:0003413 [chondrocyte differentiation involved in endochondral bone morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009950 [dorsal/ventral axis specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010942 [positive regulation of cell death]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030154 [cell differentiation]
GO:0030282 [bone mineralization]
GO:0030877 [beta-catenin destruction complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032423 [regulation of mismatch repair]
GO:0034613 [cellular protein localization]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0042476 [odontogenesis]
GO:0043547 [positive regulation of GTPase activity]
GO:0043570 [maintenance of DNA repeat elements]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0048255 [mRNA stabilization]
GO:0061181 [regulation of chondrocyte development]
GO:0070016 [armadillo repeat domain binding]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 843 aa
93.6 kDa 		No 0
AXIN2-004
ENSP00000364854
ENST00000375702
E7ES00 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 778 aa
86.7 kDa 		No 0
AXIN2-005
ENSP00000463761
ENST00000580513
J3QQJ3 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 192 aa
21.6 kDa 		Yes 0
AXIN2-006
ENSP00000464264
ENST00000577278
J3QRK4 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 271 aa
30.1 kDa 		No 0
AXIN2-007
ENSP00000463192
ENST00000585045
J3QQJ3 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 192 aa
21.6 kDa 		Yes 0
AXIN2-008
ENSP00000441151
ENST00000544103
F5GX43 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 151 aa
16.8 kDa 		Yes 0
AXIN2-201
ENSP00000481191
ENST00000611991
A0A087WXP8 [Direct mapping]
Axin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 160 aa
18 kDa 		Yes 0
AXIN2-202
ENSP00000478916
ENST00000618960
E7ES00 [Direct mapping]
Axin-2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001957 [intramembranous ossification]
GO:0005096 [GTPase activator activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
 778 aa
86.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.