Expression of AXIN2 in cancer - Summary

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	AXIN2
Gene descriptionⁱ Gene description according to HGNC.	Axin 2
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, CACO-2, Hep G2)
HPA (normal tissue):	Mixed

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Approved based on 2 antibodies. CAB012283 , CAB017783
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

CAB012283	CAB017783

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	AXIN2 (HGNC Symbol)
Synonyms	DKFZp781B0869, MGC126582
Description	Axin 2 (HGNC Symbol)
Entrez gene summary	The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q24.1
Chromosome location (bp)	65528563 - 65561647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168646 (version 83.38)
Entrez gene	8313
UniProt	Q9Y2T1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2T1
Antibodypedia	AXIN2 antibodies

PROTEIN BROWSERⁱ

AXIN2-001	AXIN2-004	AXIN2-005	AXIN2-006	AXIN2-007	AXIN2-008	AXIN2-201	AXIN2-202

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AXIN2-001 ENSP00000302625 ENST00000307078	Q9Y2T1 [Direct mapping] Axin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001756 [somitogenesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0001957 [intramembranous ossification] GO:0003139 [secondary heart field specification] GO:0003413 [chondrocyte differentiation involved in endochondral bone morphogenesis] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009950 [dorsal/ventral axis specification] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010942 [positive regulation of cell death] GO:0014069 [postsynaptic density] GO:0015630 [microtubule cytoskeleton] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030111 [regulation of Wnt signaling pathway] GO:0030154 [cell differentiation] GO:0030282 [bone mineralization] GO:0030877 [beta-catenin destruction complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032423 [regulation of mismatch repair] GO:0034613 [cellular protein localization] GO:0035414 [negative regulation of catenin import into nucleus] GO:0042476 [odontogenesis] GO:0043547 [positive regulation of GTPase activity] GO:0043570 [maintenance of DNA repeat elements] GO:0045668 [negative regulation of osteoblast differentiation] GO:0048255 [mRNA stabilization] GO:0061181 [regulation of chondrocyte development] GO:0070016 [armadillo repeat domain binding] GO:0070411 [I-SMAD binding] GO:0070602 [regulation of centromeric sister chromatid cohesion] GO:0071407 [cellular response to organic cyclic compound] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090244 [Wnt signaling pathway involved in somitogenesis] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	843 aa 93.6 kDa	No	0
AXIN2-004 ENSP00000364854 ENST00000375702	E7ES00 [Direct mapping] Axin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0015630 [microtubule cytoskeleton] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	778 aa 86.7 kDa	No	0
AXIN2-005 ENSP00000463761 ENST00000580513	J3QQJ3 [Direct mapping] Axin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	192 aa 21.6 kDa	Yes	0
AXIN2-006 ENSP00000464264 ENST00000577278	J3QRK4 [Direct mapping] Axin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	271 aa 30.1 kDa	No	0
AXIN2-007 ENSP00000463192 ENST00000585045	J3QQJ3 [Direct mapping] Axin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	192 aa 21.6 kDa	Yes	0
AXIN2-008 ENSP00000441151 ENST00000544103	F5GX43 [Direct mapping] Axin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	151 aa 16.8 kDa	Yes	0
AXIN2-201 ENSP00000481191 ENST00000611991	A0A087WXP8 [Direct mapping] Axin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	160 aa 18 kDa	Yes	0
AXIN2-202 ENSP00000478916 ENST00000618960	E7ES00 [Direct mapping] Axin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0005096 [GTPase activator activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006355 [regulation of transcription, DNA-templated] GO:0008013 [beta-catenin binding] GO:0008219 [cell death] GO:0009950 [dorsal/ventral axis specification] GO:0014069 [postsynaptic density] GO:0015630 [microtubule cytoskeleton] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0043547 [positive regulation of GTPase activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0070016 [armadillo repeat domain binding] GO:0071407 [cellular response to organic cyclic compound] GO:0090244 [Wnt signaling pathway involved in somitogenesis] Show all	778 aa 86.7 kDa	No	0