Cell atlas - GSTM4 - The Human Protein Atlas

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GSTM4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	GSTM4
Gene description	Glutathione S-transferase mu 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048652
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048652	A-431	Mitochondria
	HPA048652	U-2 OS	Mitochondria
	HPA048652	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	GSTM4
Synonyms
Description	Glutathione S-transferase mu 4 (HGNC Symbol)
Entrez gene summary	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	109656081 - 109674836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168765 (version 83.38)
Entrez gene	2948
UniProt	Q03013 (UniProt - Evidence at protein level)
neXtProt	NX_Q03013
Antibodypedia	GSTM4 antibodies

PROTEIN BROWSER

GSTM4-001	GSTM4-002	GSTM4-003	GSTM4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSTM4-001 ENSP00000358851 ENST00000369836	Q03013 [Direct mapping] Glutathione S-transferase Mu 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0018916 [nitrobenzene metabolic process] GO:0019899 [enzyme binding] GO:0042178 [xenobiotic catabolic process] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	218 aa 25.6 kDa	No	0
GSTM4-002 ENSP00000358848 ENST00000369833	A6NNT0 [Direct mapping] Glutathione S-transferase Mu 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	202 aa 23 kDa	No	0
GSTM4-003 ENSP00000316471 ENST00000326729	Q03013 [Direct mapping] Glutathione S-transferase Mu 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0019899 [enzyme binding] GO:0042178 [xenobiotic catabolic process] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	195 aa 22.8 kDa	No	0
GSTM4-201 ENSP00000336744 ENST00000336075	A0A0A0MR85 [Direct mapping] Glutathione S-transferase Mu 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	218 aa 25.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.