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GSTM4

GENERAL INFORMATION

Gene name

 GSTM4

Gene description

 Glutathione S-transferase mu 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA048652 , HPA055972 , HPA055973
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048652
HPA055972
HPA055973

GENE INFORMATION

Gene name

 GSTM4

Synonyms

Description

 Glutathione S-transferase mu 4 (HGNC Symbol)

Entrez gene summary

 Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109656081 - 109674836

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168765 (version 83.38)

Entrez gene

 2948

UniProt

 Q03013 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03013

Antibodypedia

 GSTM4 antibodies

PROTEIN BROWSER
GSTM4-001
GSTM4-002
GSTM4-003
GSTM4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSTM4-001
ENSP00000358851
ENST00000369836
Q03013 [Direct mapping]
Glutathione S-transferase Mu 4
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0018916 [nitrobenzene metabolic process]
GO:0019899 [enzyme binding]
GO:0042178 [xenobiotic catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:1901687 [glutathione derivative biosynthetic process]
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 218 aa
25.6 kDa 		No 0
GSTM4-002
ENSP00000358848
ENST00000369833
A6NNT0 [Direct mapping]
Glutathione S-transferase Mu 4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
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 202 aa
23 kDa 		No 0
GSTM4-003
ENSP00000316471
ENST00000326729
Q03013 [Direct mapping]
Glutathione S-transferase Mu 4
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0019899 [enzyme binding]
GO:0042178 [xenobiotic catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:1901687 [glutathione derivative biosynthetic process]
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 195 aa
22.8 kDa 		No 0
GSTM4-201
ENSP00000336744
ENST00000336075
A0A0A0MR85 [Direct mapping]
Glutathione S-transferase Mu 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
Show all
 218 aa
25.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.