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Most cancer tissues showed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
IL12A (HGNC Symbol)
Synonyms
CLMF, IL-12A, NFSK, NKSF1, p35
Description
Interleukin 12A (HGNC Symbol)
Entrez gene summary
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]