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IL12A

GENERAL INFORMATION

Gene name

 IL12A

Gene description

 Interleukin 12A

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA001886
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 IL12A (HGNC Symbol)

Synonyms

 CLMF, IL-12A, NFSK, NKSF1, p35

Description

 Interleukin 12A (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q25.33

Chromosome location (bp)

 159988750 - 159996019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168811 (version 83.38)

Entrez gene

 3592

UniProt

 P29459 (UniProt - Evidence at protein level)

neXtProt

 NX_P29459

Antibodypedia

 IL12A antibodies

PROTEIN BROWSER
IL12A-001
IL12A-005
IL12A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL12A-001
ENSP00000303231
ENST00000305579
P29459 [Direct mapping]
Interleukin-12 subunit alpha
O60595 [Target identity:100%; Query identity:100%]
Interleukin 12; Interleukin 12, P35; Interleukin 12A (Natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); Interleukin 12A (Natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target]
GO:0005125 [cytokine activity]
GO:0005143 [interleukin-12 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0008083 [growth factor activity]
GO:0009615 [response to virus]
GO:0010224 [response to UV-B]
GO:0016477 [cell migration]
GO:0032496 [response to lipopolysaccharide]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032816 [positive regulation of natural killer cell activation]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0034393 [positive regulation of smooth muscle cell apoptotic process]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042163 [interleukin-12 beta subunit binding]
GO:0042520 [positive regulation of tyrosine phosphorylation of Stat4 protein]
GO:0042832 [defense response to protozoan]
GO:0043514 [interleukin-12 complex]
GO:0045513 [interleukin-27 binding]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046982 [protein heterodimerization activity]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051135 [positive regulation of NK T cell activation]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:2000510 [positive regulation of dendritic cell chemotaxis]
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 253 aa
28.3 kDa 		No 1
IL12A-005
ENSP00000420184
ENST00000480787
E7ENE1 [Direct mapping]
Interleukin-12 subunit alpha
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005143 [interleukin-12 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042163 [interleukin-12 beta subunit binding]
GO:0043514 [interleukin-12 complex]
GO:0046982 [protein heterodimerization activity]
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 215 aa
24 kDa 		No 1
IL12A-006
ENSP00000419046
ENST00000466512
E9PGR3 [Direct mapping]
Interleukin-12 subunit alpha
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005143 [interleukin-12 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042163 [interleukin-12 beta subunit binding]
GO:0043514 [interleukin-12 complex]
GO:0046982 [protein heterodimerization activity]
Show all
 239 aa
26.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.