Expression of TM4SF20 in cancer - Summary - The Human Protein Atlas

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TM4SF20

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TM4SF20
Gene description	Transmembrane 4 L six family member 20
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Cell line enhanced (A549, RPMI-8226)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in the small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA051838 , HPA063184
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051838	HPA063184

GENE INFORMATION
Gene name	TM4SF20 (HGNC Symbol)
Synonyms	FLJ22800, TCCE518
Description	Transmembrane 4 L six family member 20 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q36.3
Chromosome location (bp)	227362156 - 227381995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168955 (version 83.38)
Entrez gene	79853
UniProt	Q53R12 (UniProt - Evidence at transcript level)
neXtProt	NX_Q53R12
Antibodypedia	TM4SF20 antibodies

PROTEIN BROWSER

TM4SF20-001	TM4SF20-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM4SF20-001 ENSP00000303028 ENST00000304568	Q53R12 [Direct mapping] Transmembrane 4 L6 family member 20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	229 aa 25.1 kDa	No	3
TM4SF20-002 ENSP00000416565 ENST00000449706	C9JES4 [Direct mapping] Transmembrane 4 L6 family member 20 Show all	Predicted intracellular proteins Show all		14 aa 1.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.