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JMJD7-PLA2G4B

GENERAL INFORMATION

Gene name

 JMJD7-PLA2G4B

Gene description

 JMJD7-PLA2G4B readthrough

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA005726
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005726

GENE INFORMATION

Gene name

 JMJD7-PLA2G4B

Synonyms

Description

 JMJD7-PLA2G4B readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41828095 - 41848155

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168970 (version 83.38)

Entrez gene

 8681

UniProt

 P0C869 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C869

Antibodypedia

 JMJD7-PLA2G4B antibodies

PROTEIN BROWSER
JMJD7-PLA2G4B-001
JMJD7-PLA2G4B-002
JMJD7-PLA2G4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
JMJD7-PLA2G4B-001
ENSP00000371886
ENST00000382448
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
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GO:0004620 [phospholipase activity]
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0009395 [phospholipid catabolic process]
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 1012 aa
114.1 kDa 		No 0
JMJD7-PLA2G4B-002
ENSP00000342785
ENST00000342159
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
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GO:0004620 [phospholipase activity]
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0009395 [phospholipid catabolic process]
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 893 aa
100.5 kDa 		No 0
JMJD7-PLA2G4B-201
ENSP00000416610
ENST00000458483
P0C869 [Direct mapping]
Cytosolic phospholipase A2 beta
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
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GO:0004620 [phospholipase activity]
GO:0004622 [lysophospholipase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006954 [inflammatory response]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0009395 [phospholipid catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019722 [calcium-mediated signaling]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031901 [early endosome membrane]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0046475 [glycerophospholipid catabolic process]
GO:0047498 [calcium-dependent phospholipase A2 activity]
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 781 aa
88 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.