Cell atlas - CHST14 - The Human Protein Atlas

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CHST14

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CHST14
Gene description	Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057697
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057697	HaCaT	Vesicles
	HPA057697	RH-30	No staining
	HPA057697	U-2 OS	No staining

GENE INFORMATION
Gene name	CHST14 (HGNC Symbol)
Synonyms	D4ST-1, D4ST1, HD4ST
Description	Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40470998 - 40474571
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169105 (version 83.38)
Entrez gene	113189
UniProt	Q8NCH0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCH0
Antibodypedia	CHST14 antibodies

PROTEIN BROWSER

CHST14-001	CHST14-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST14-001 ENSP00000307297 ENST00000306243	Q8NCH0 [Direct mapping] Carbohydrate sulfotransferase 14 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0042301 [phosphate ion binding] GO:0044281 [small molecule metabolic process] GO:0050655 [dermatan sulfate proteoglycan metabolic process] GO:0070062 [extracellular exosome] Show all	376 aa 43 kDa	No	1
CHST14-002 ENSP00000453882 ENST00000559991	H0YN65 [Direct mapping] Carbohydrate sulfotransferase 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	351 aa 39.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.