Expression of CHST14 in cancer - Summary

GENERAL INFORMATION
Gene name	CHST14
Gene description	Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most glandular cells, including expression in pituitary gland,

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA071601
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA071601

GENE INFORMATION
Gene name	CHST14 (HGNC Symbol)
Synonyms	D4ST-1, D4ST1, HD4ST
Description	Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40470998 - 40474571
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169105 (version 83.38)
Entrez gene	113189
UniProt	Q8NCH0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCH0
Antibodypedia	CHST14 antibodies

PROTEIN BROWSER

CHST14-001	CHST14-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST14-001 ENSP00000307297 ENST00000306243	Q8NCH0 [Direct mapping] Carbohydrate sulfotransferase 14 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0042301 [phosphate ion binding] GO:0044281 [small molecule metabolic process] GO:0050655 [dermatan sulfate proteoglycan metabolic process] GO:0070062 [extracellular exosome] Show all	376 aa 43 kDa	No	1
CHST14-002 ENSP00000453882 ENST00000559991	H0YN65 [Direct mapping] Carbohydrate sulfotransferase 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	351 aa 39.9 kDa	No	1