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CD2BP2

GENERAL INFORMATION

Gene name

 CD2BP2

Gene description

 CD2 (cytoplasmic tail) binding protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041508 , HPA061309
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041508
HPA061309

GENE INFORMATION

Gene name

 CD2BP2 (HGNC Symbol)

Synonyms

 LIN1, PPP1R59, Snu40

Description

 CD2 (cytoplasmic tail) binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30350766 - 30355361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169217 (version 83.38)

Entrez gene

 10421

UniProt

 O95400 (UniProt - Evidence at protein level)

neXtProt

 NX_O95400

Antibodypedia

 CD2BP2 antibodies

PROTEIN BROWSER
CD2BP2-001
CD2BP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD2BP2-001
ENSP00000304903
ENST00000305596
O95400 [Direct mapping]
CD2 antigen cytoplasmic tail-binding protein 2
A0A024QZC1 [Target identity:100%; Query identity:100%]
CD2 antigen (Cytoplasmic tail) binding protein 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016607 [nuclear speck]
GO:0043021 [ribonucleoprotein complex binding]
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 341 aa
37.6 kDa 		No 0
CD2BP2-002
ENSP00000456935
ENST00000569466
O95400 [Direct mapping]
CD2 antigen cytoplasmic tail-binding protein 2
A0A024QZC1 [Target identity:100%; Query identity:100%]
CD2 antigen (Cytoplasmic tail) binding protein 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016607 [nuclear speck]
GO:0043021 [ribonucleoprotein complex binding]
Show all
 341 aa
37.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.