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SIN3 transcription regulator family member A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Q96ST3 [Direct mapping] Paired amphipathic helix protein Sin3a
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THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000776 [kinetochore] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0001701 [in utero embryonic development] GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0003723 [RNA binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0010243 [response to organonitrogen compound] GO:0010467 [gene expression] GO:0010817 [regulation of hormone levels] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016575 [histone deacetylation] GO:0016580 [Sin3 complex] GO:0017053 [transcriptional repressor complex] GO:0031937 [positive regulation of chromatin silencing] GO:0032403 [protein complex binding] GO:0033558 [protein deacetylase activity] GO:0034613 [cellular protein localization] GO:0040029 [regulation of gene expression, epigenetic] GO:0042754 [negative regulation of circadian rhythm] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045171 [intercellular bridge] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:0051595 [response to methylglyoxal] GO:0071333 [cellular response to glucose stimulus] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901675 [negative regulation of histone H3-K27 acetylation] GO:1903351 [cellular response to dopamine] GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Q96ST3 [Direct mapping] Paired amphipathic helix protein Sin3a
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007596 [blood coagulation] GO:0010467 [gene expression] GO:0016575 [histone deacetylation] GO:0016580 [Sin3 complex] GO:0031937 [positive regulation of chromatin silencing] GO:0033558 [protein deacetylase activity] GO:0040029 [regulation of gene expression, epigenetic] GO:0042754 [negative regulation of circadian rhythm] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045171 [intercellular bridge] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901675 [negative regulation of histone H3-K27 acetylation] GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Q96ST3 [Direct mapping] Paired amphipathic helix protein Sin3a
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007596 [blood coagulation] GO:0010467 [gene expression] GO:0016575 [histone deacetylation] GO:0016580 [Sin3 complex] GO:0031937 [positive regulation of chromatin silencing] GO:0033558 [protein deacetylase activity] GO:0040029 [regulation of gene expression, epigenetic] GO:0042754 [negative regulation of circadian rhythm] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045171 [intercellular bridge] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048511 [rhythmic process] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901675 [negative regulation of histone H3-K27 acetylation] GO:2000678 [negative regulation of transcription regulatory region DNA binding]