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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CXCL8
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CXCL8

Gene description

Chemokine (C-X-C motif) ligand 8

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (BJ hTERT+)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 1 antibody.
HPA057179
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

HPA057179

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of lymphomas and melanomas displayed moderate cytoplasmic positivity. Moderate nuclear positivity was observed in rare cases of endometrial cancers. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

CXCL8 (HGNC Symbol)

Synonyms

3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1

Description

Chemokine (C-X-C motif) ligand 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73740506 - 73743716

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169429 (version 83.38)

Entrez gene

3576

UniProt

P10145 (UniProt - Evidence at protein level)

neXtProt

NX_P10145

Antibodypedia

CXCL8 antibodies

PROTEIN BROWSER

CXCL8-001
CXCL8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCL8-001
ENSP00000306512
ENST00000307407
P10145 [Direct mapping]
Interleukin-8 MDNCF-a Interleukin-8 IL-8(5-77) IL-8(6-77) IL-8(7-77) IL-8(8-77) IL-8(9-77)
A0A024RDA5 [Target identity:100%; Query identity:100%]
C-X-C motif chemokine
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Show all
GO:0001525 [angiogenesis]
GO:0002237 [response to molecule of bacterial origin]
GO:0005153 [interleukin-8 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0019722 [calcium-mediated signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030593 [neutrophil chemotaxis]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031623 [receptor internalization]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035556 [intracellular signal transduction]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042119 [neutrophil activation]
GO:0043312 [neutrophil degranulation]
GO:0044267 [cellular protein metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045091 [regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0048566 [embryonic digestive tract development]
GO:0050930 [induction of positive chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
99 aa
11.1 kDa
Yes 0
CXCL8-002
ENSP00000385908
ENST00000401931
C9J4T6 [Direct mapping]
C-X-C motif chemokine
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0043312 [neutrophil degranulation]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
95 aa
10.7 kDa
Yes 0

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