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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CXCL8
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CXCL8

Gene description

Chemokine (C-X-C motif) ligand 8

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several lymphoid tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 1 antibody.
HPA057179
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION

Gene name

CXCL8 (HGNC Symbol)

Synonyms

3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1

Description

Chemokine (C-X-C motif) ligand 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73740506 - 73743716

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169429 (version 83.38)

Entrez gene

3576

UniProt

P10145 (UniProt - Evidence at protein level)

neXtProt

NX_P10145

Antibodypedia

CXCL8 antibodies

PROTEIN BROWSER

CXCL8-001
CXCL8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCL8-001
ENSP00000306512
ENST00000307407
P10145 [Direct mapping]
Interleukin-8 MDNCF-a Interleukin-8 IL-8(5-77) IL-8(6-77) IL-8(7-77) IL-8(8-77) IL-8(9-77)
A0A024RDA5 [Target identity:100%; Query identity:100%]
C-X-C motif chemokine
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   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Show all
GO:0001525 [angiogenesis]
GO:0002237 [response to molecule of bacterial origin]
GO:0005153 [interleukin-8 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0019722 [calcium-mediated signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030593 [neutrophil chemotaxis]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031623 [receptor internalization]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035556 [intracellular signal transduction]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042119 [neutrophil activation]
GO:0043312 [neutrophil degranulation]
GO:0044267 [cellular protein metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045091 [regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0048566 [embryonic digestive tract development]
GO:0050930 [induction of positive chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
99 aa
11.1 kDa
Yes 0
CXCL8-002
ENSP00000385908
ENST00000401931
C9J4T6 [Direct mapping]
C-X-C motif chemokine
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0043312 [neutrophil degranulation]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
95 aa
10.7 kDa
Yes 0

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