Cell atlas - SDC2 - The Human Protein Atlas

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SDC2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SDC2
Gene description	Syndecan 2
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane.
RNA cell category	Cell line enhanced (AF22, U-138 MG, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044416
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, U-138 MG, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

Cytosol (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044416	HEK 293	Cytosol
	HPA044416	Hep G2	Plasma membrane
	HPA044416	Hep G2	Cytosol
	HPA044416	U-2 OS	Plasma membrane
	HPA044416	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SDC2 (HGNC Symbol)
Synonyms	CD362, fibroglycan, HSPG, HSPG1, SYND2
Description	Syndecan 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	96493351 - 96611780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169439 (version 83.38)
Entrez gene	6383
UniProt	P34741 (UniProt - Evidence at protein level)
neXtProt	NX_P34741
Antibodypedia	SDC2 antibodies

PROTEIN BROWSER

SDC2-001	SDC2-002	SDC2-003	SDC2-004	SDC2-005	SDC2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDC2-001 ENSP00000307046 ENST00000302190	P34741 [Direct mapping] Syndecan-2 A0A024R9D1 [Target identity:100%; Query identity:100%] Syndecan Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001666 [response to hypoxia] GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0007411 [axon guidance] GO:0007603 [phototransduction, visible light] GO:0008150 [biological_process] GO:0008218 [bioluminescence] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030165 [PDZ domain binding] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0031000 [response to caffeine] GO:0042060 [wound healing] GO:0043025 [neuronal cell body] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0048013 [ephrin receptor signaling pathway] GO:0048813 [dendrite morphogenesis] GO:0048814 [regulation of dendrite morphogenesis] Show all	201 aa 22.2 kDa	Yes	1
SDC2-002 ENSP00000429045 ENST00000518385	E7ESK6 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	165 aa 18.4 kDa	Yes	1
SDC2-003 ENSP00000428256 ENST00000519914	E9PBI9 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	172 aa 19 kDa	No	1
SDC2-004 ENSP00000429121 ENST00000521590	E5RJB8 [Direct mapping] Syndecan-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	137 aa 14.9 kDa	No	1
SDC2-005 ENSP00000429662 ENST00000523877	E5RHU3 [Direct mapping] Syndecan-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	145 aa 16 kDa	No	1
SDC2-006 ENSP00000427784 ENST00000522911	E9PBI9 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	172 aa 19 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.