Tissue expression of SDC2 - Summary - The Human Protein Atlas

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SDC2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SDC2
Gene description	Syndecan 2
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB025123
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SDC2 (HGNC Symbol)
Synonyms	CD362, fibroglycan, HSPG, HSPG1, SYND2
Description	Syndecan 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	96493351 - 96611780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169439 (version 83.38)
Entrez gene	6383
UniProt	P34741 (UniProt - Evidence at protein level)
neXtProt	NX_P34741
Antibodypedia	SDC2 antibodies

PROTEIN BROWSER

SDC2-001	SDC2-002	SDC2-003	SDC2-004	SDC2-005	SDC2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDC2-001 ENSP00000307046 ENST00000302190	P34741 [Direct mapping] Syndecan-2 A0A024R9D1 [Target identity:100%; Query identity:100%] Syndecan Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001666 [response to hypoxia] GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0007411 [axon guidance] GO:0007603 [phototransduction, visible light] GO:0008150 [biological_process] GO:0008218 [bioluminescence] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030165 [PDZ domain binding] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0031000 [response to caffeine] GO:0042060 [wound healing] GO:0043025 [neuronal cell body] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0048013 [ephrin receptor signaling pathway] GO:0048813 [dendrite morphogenesis] GO:0048814 [regulation of dendrite morphogenesis] Show all	201 aa 22.2 kDa	Yes	1
SDC2-002 ENSP00000429045 ENST00000518385	E7ESK6 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	165 aa 18.4 kDa	Yes	1
SDC2-003 ENSP00000428256 ENST00000519914	E9PBI9 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	172 aa 19 kDa	No	1
SDC2-004 ENSP00000429121 ENST00000521590	E5RJB8 [Direct mapping] Syndecan-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	137 aa 14.9 kDa	No	1
SDC2-005 ENSP00000429662 ENST00000523877	E5RHU3 [Direct mapping] Syndecan-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	145 aa 16 kDa	No	1
SDC2-006 ENSP00000427784 ENST00000522911	E9PBI9 [Direct mapping] Syndecan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0048813 [dendrite morphogenesis] Show all	172 aa 19 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.