Cell atlas - PLEKHA2 - The Human Protein Atlas

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PLEKHA2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PLEKHA2
Gene description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus, cytosol & nuclear bodies.
RNA cell category	Cell line enhanced (Daudi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain), Nuclear bodies (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA004706
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus, cytosol & nuclear bodies.

Main location

Nucleus (uncertain), Nuclear bodies (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004706	A-431	Cytosol
	HPA004706	U-2 OS	Nucleus
			Nuclear bodies
			Cytosol
	HPA004706	U-251 MG	Nucleus
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	PLEKHA2 (HGNC Symbol)
Synonyms	TAPP2
Description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	38901235 - 38973909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169499 (version 83.38)
Entrez gene	59339
UniProt
neXtProt
Antibodypedia	PLEKHA2 antibodies

PROTEIN BROWSER

PLEKHA2-001	PLEKHA2-002	PLEKHA2-003	PLEKHA2-005	PLEKHA2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA2-001 ENSP00000482228 ENST00000617275	A8K727 [Direct mapping] Pleckstrin homology domain-containing family A member 2; cDNA FLJ75843, highly similar to Homo sapiens pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (PLEKHA2), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0030165 [PDZ domain binding] Show all	425 aa 47.2 kDa	No	0
PLEKHA2-002 ENSP00000430938 ENST00000521746	E5RHB5 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		249 aa 27.8 kDa	No	0
PLEKHA2-003 ENSP00000483078 ENST00000616834	A0A087X038 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		376 aa 41.6 kDa	No	0
PLEKHA2-005 ENSP00000482319 ENST00000616927	A0A087WZ32 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		375 aa 41.2 kDa	No	0
PLEKHA2-008 ENSP00000429956 ENST00000519640	E5RGP3 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.