Expression of PLEKHA2 in cancer - Summary - The Human Protein Atlas

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PLEKHA2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLEKHA2
Gene description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA004706
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004706

GENE INFORMATION
Gene name	PLEKHA2 (HGNC Symbol)
Synonyms	TAPP2
Description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	38901235 - 38973909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169499 (version 83.38)
Entrez gene	59339
UniProt
neXtProt
Antibodypedia	PLEKHA2 antibodies

PROTEIN BROWSER

PLEKHA2-001	PLEKHA2-002	PLEKHA2-003	PLEKHA2-005	PLEKHA2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA2-001 ENSP00000482228 ENST00000617275	A8K727 [Direct mapping] Pleckstrin homology domain-containing family A member 2; cDNA FLJ75843, highly similar to Homo sapiens pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (PLEKHA2), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0030165 [PDZ domain binding] Show all	425 aa 47.2 kDa	No	0
PLEKHA2-002 ENSP00000430938 ENST00000521746	E5RHB5 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		249 aa 27.8 kDa	No	0
PLEKHA2-003 ENSP00000483078 ENST00000616834	A0A087X038 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		376 aa 41.6 kDa	No	0
PLEKHA2-005 ENSP00000482319 ENST00000616927	A0A087WZ32 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		375 aa 41.2 kDa	No	0
PLEKHA2-008 ENSP00000429956 ENST00000519640	E5RGP3 [Direct mapping] Pleckstrin homology domain-containing family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.