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CLIC4

GENERAL INFORMATION

Gene name

 CLIC4

Gene description

 Chloride intracellular channel 4

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in a subset of tissues including kidney tubules, salivary gland and epididymis as well as endothelial cells in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA008019 , HPA060804
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CLIC4 (HGNC Symbol)

Synonyms

 CLIC4L, DKFZP566G223, H1, huH1, P64H1

Description

 Chloride intracellular channel 4 (HGNC Symbol)

Entrez gene summary

 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 24745357 - 24844324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169504 (version 83.38)

Entrez gene

 25932

UniProt

 Q9Y696 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y696

Antibodypedia

 CLIC4 antibodies

PROTEIN BROWSER
CLIC4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC4-001
ENSP00000363500
ENST00000374379
Q9Y696 [Direct mapping]
Chloride intracellular channel protein 4
Q6FIC5 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001886 [endothelial cell morphogenesis]
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005911 [cell-cell junction]
GO:0006821 [chloride transport]
GO:0006915 [apoptotic process]
GO:0007035 [vacuolar acidification]
GO:0009566 [fertilization]
GO:0009986 [cell surface]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0030496 [midbody]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035088 [establishment or maintenance of apical/basal cell polarity]
GO:0035264 [multicellular organism growth]
GO:0045177 [apical part of cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051493 [regulation of cytoskeleton organization]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0070062 [extracellular exosome]
GO:0071277 [cellular response to calcium ion]
GO:1902476 [chloride transmembrane transport]
Show all
 253 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.