Cell atlas - CLIC3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CLIC3

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CLIC3
Gene description	Chloride intracellular channel 3
Protein class	Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Cell line enhanced (BEWO, T-47d, MCF7, TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA005963
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, T-47d, MCF7, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005963	A-431	Nuclear bodies
	HPA005963	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	CLIC3
Synonyms
Description	Chloride intracellular channel 3 (HGNC Symbol)
Entrez gene summary	Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136994635 - 136996803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169583 (version 83.38)
Entrez gene	9022
UniProt	O95833 (UniProt - Evidence at protein level)
neXtProt	NX_O95833
Antibodypedia	CLIC3 antibodies

PROTEIN BROWSER

CLIC3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLIC3-001 ENSP00000419378 ENST00000494426	O95833 [Direct mapping] Chloride intracellular channel protein 3 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006821 [chloride transport] GO:0007165 [signal transduction] GO:0034707 [chloride channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] Show all	236 aa 26.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.