Expression of CLIC3 in cancer - Summary

GENERAL INFORMATION
Gene name	CLIC3
Gene description	Chloride intracellular channel 3
Protein class	Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enhanced (BEWO, MCF7, T-47d, TIME)
HPA (normal tissue):	Tissue enhanced (esophagus, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues, highly abundant in thyroid gland and placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA005963
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005963

GENE INFORMATION
Gene name	CLIC3
Synonyms
Description	Chloride intracellular channel 3 (HGNC Symbol)
Entrez gene summary	Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136994635 - 136996803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169583 (version 83.38)
Entrez gene	9022
UniProt	O95833 (UniProt - Evidence at protein level)
neXtProt	NX_O95833
Antibodypedia	CLIC3 antibodies

PROTEIN BROWSER

CLIC3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLIC3-001 ENSP00000419378 ENST00000494426	O95833 [Direct mapping] Chloride intracellular channel protein 3 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006821 [chloride transport] GO:0007165 [signal transduction] GO:0034707 [chloride channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] Show all	236 aa 26.6 kDa	No	0