Expression of GKN1 in cancer - Summary - The Human Protein Atlas

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GKN1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GKN1
Gene description	Gastrokine 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Group enriched (HaCaT, HMC-1, MOLT-4, NTERA-2, REH, U-2 OS, U-266/70)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stomach

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA047684
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and urothelial cancer (favourable).
Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047684

GENE INFORMATION
Gene name	GKN1 (HGNC Symbol)
Synonyms	AMP18, BRICD1, CA11
Description	Gastrokine 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	68974573 - 68980974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169605 (version 83.38)
Entrez gene	56287
UniProt	Q9NS71 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NS71
Antibodypedia	GKN1 antibodies

PROTEIN BROWSER

GKN1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GKN1-001 ENSP00000367172 ENST00000377938	Q9NS71 [Direct mapping] Gastrokine-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0007586 [digestion] GO:0051781 [positive regulation of cell division] Show all	199 aa 22 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.