Expression of CKAP2L in cancer - Summary - The Human Protein Atlas

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CKAP2L

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CKAP2L
Gene description	Cytoskeleton associated protein 2-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (bone marrow, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA039407 , HPA040057
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039407	HPA040057

GENE INFORMATION
Gene name	CKAP2L (HGNC Symbol)
Synonyms	FLJ40629, radmis
Description	Cytoskeleton associated protein 2-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	112736607 - 112764677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169607 (version 83.38)
Entrez gene	150468
UniProt	Q8IYA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYA6
Antibodypedia	CKAP2L antibodies

PROTEIN BROWSER

CKAP2L-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKAP2L-001 ENSP00000305204 ENST00000302450	Q8IYA6 [Direct mapping] Cytoskeleton-associated protein 2-like Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	745 aa 83.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.