Expression of ACTRT2 in cancer - Summary - The Human Protein Atlas

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ACTRT2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTRT2
Gene description	Actin-related protein T2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006480 , HPA025079
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006480	HPA025079

GENE INFORMATION
Gene name	ACTRT2 (HGNC Symbol)
Synonyms	Arp-T2, ARPM2, FLJ25424
Description	Actin-related protein T2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	3021483 - 3022903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169717 (version 83.38)
Entrez gene	140625
UniProt	Q8TDY3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDY3
Antibodypedia	ACTRT2 antibodies

PROTEIN BROWSER

ACTRT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTRT2-001 ENSP00000367658 ENST00000378404	Q8TDY3 [Direct mapping] Actin-related protein T2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] Show all	377 aa 41.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.