Cell atlas - LDB2 - The Human Protein Atlas

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LDB2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LDB2
Gene description	LIM domain binding 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli.
RNA cell category	Cell line enhanced (HUVEC TERT2, U-138 MG, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA068634
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, U-138 MG, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli.

Main location

Nucleus (supported), Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA068634	AF22	Nucleoli	Intensity
	HPA068634	BJ	Nucleus
	HPA068634	U-2 OS	Nucleus
			Nucleoli	Intensity
			Plasma membrane

GENE INFORMATION
Gene name	LDB2 (HGNC Symbol)
Synonyms	CLIM1, LDB1
Description	LIM domain binding 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	4
Cytoband	p15.32
Chromosome location (bp)	16501541 - 16898809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169744 (version 83.38)
Entrez gene	9079
UniProt	O43679 (UniProt - Evidence at protein level)
neXtProt	NX_O43679
Antibodypedia	LDB2 antibodies

PROTEIN BROWSER

LDB2-001	LDB2-003	LDB2-004	LDB2-005	LDB2-007	LDB2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LDB2-001 ENSP00000306772 ENST00000304523	O43679 [Direct mapping] LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000989 [transcription factor activity, transcription factor binding] GO:0001942 [hair follicle development] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0010669 [epithelial structure maintenance] GO:0019899 [enzyme binding] GO:0030274 [LIM domain binding] GO:0035019 [somatic stem cell population maintenance] GO:0044089 [positive regulation of cellular component biogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	373 aa 42.8 kDa	No	0
LDB2-003 ENSP00000392089 ENST00000441778	O43679 [Direct mapping] LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0030274 [LIM domain binding] Show all	331 aa 38 kDa	No	0
LDB2-004 ENSP00000423963 ENST00000502640	E9PFI4 [Direct mapping] LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030274 [LIM domain binding] Show all	313 aa 36.1 kDa	No	0
LDB2-005 ENSP00000425754 ENST00000507464	H0YA09 [Direct mapping] LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030274 [LIM domain binding] Show all	294 aa 33.2 kDa	No	0
LDB2-007 ENSP00000422552 ENST00000515064	G5E9Y7 [Direct mapping] LIM domain binding 2, isoform CRA_b; LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030274 [LIM domain binding] Show all	371 aa 42.6 kDa	No	0
LDB2-010 ENSP00000421767 ENST00000506732	D6RAT1 [Direct mapping] LIM domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030274 [LIM domain binding] Show all	164 aa 19.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.