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LDB2

GENERAL INFORMATION

Gene name

 LDB2

Gene description

 LIM domain binding 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, HUVEC TERT2, U-138 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB017544
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017544

GENE INFORMATION

Gene name

 LDB2 (HGNC Symbol)

Synonyms

 CLIM1, LDB1

Description

 LIM domain binding 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 4

Cytoband

 p15.32

Chromosome location (bp)

 16501541 - 16898809

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169744 (version 83.38)

Entrez gene

 9079

UniProt

 O43679 (UniProt - Evidence at protein level)

neXtProt

 NX_O43679

Antibodypedia

 LDB2 antibodies

PROTEIN BROWSER
LDB2-001
LDB2-003
LDB2-004
LDB2-005
LDB2-007
LDB2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDB2-001
ENSP00000306772
ENST00000304523
O43679 [Direct mapping]
LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001942 [hair follicle development]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0010669 [epithelial structure maintenance]
GO:0019899 [enzyme binding]
GO:0030274 [LIM domain binding]
GO:0035019 [somatic stem cell population maintenance]
GO:0044089 [positive regulation of cellular component biogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 373 aa
42.8 kDa 		No 0
LDB2-003
ENSP00000392089
ENST00000441778
O43679 [Direct mapping]
LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005634 [nucleus]
GO:0030274 [LIM domain binding]
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 331 aa
38 kDa 		No 0
LDB2-004
ENSP00000423963
ENST00000502640
E9PFI4 [Direct mapping]
LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003712 [transcription cofactor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030274 [LIM domain binding]
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 313 aa
36.1 kDa 		No 0
LDB2-005
ENSP00000425754
ENST00000507464
H0YA09 [Direct mapping]
LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030274 [LIM domain binding]
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 294 aa
33.2 kDa 		No 0
LDB2-007
ENSP00000422552
ENST00000515064
G5E9Y7 [Direct mapping]
LIM domain binding 2, isoform CRA_b; LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003712 [transcription cofactor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030274 [LIM domain binding]
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 371 aa
42.6 kDa 		No 0
LDB2-010
ENSP00000421767
ENST00000506732
D6RAT1 [Direct mapping]
LIM domain-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030274 [LIM domain binding]
Show all
 164 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.