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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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RAC3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

RAC3

Gene description

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

Protein class

Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA047820
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable) and thyroid cancer (unfavourable).
Endometrial cancer p<0.001
Thyroid cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA047820

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of urothelial cancers, squamous and basal cell carcinomas along with a few cases of non-Hodgkins lymphomas and ovarian cancers showed moderate to strong cytoplasmic positivity. Remaining cancers were negative.

GENE INFORMATION

Gene name

RAC3

Synonyms

Description

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

82031624 - 82034204

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169750 (version 83.38)

Entrez gene

5881

UniProt

P60763 (UniProt - Evidence at protein level)

neXtProt

NX_P60763

Antibodypedia

RAC3 antibodies

PROTEIN BROWSER

RAC3-001
RAC3-002
RAC3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAC3-001
ENSP00000304283
ENST00000306897
P60763 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0012505 [endomembrane system]
GO:0014041 [regulation of neuron maturation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0021894 [cerebral cortex GABAergic interneuron development]
GO:0022604 [regulation of cell morphogenesis]
GO:0030027 [lamellipodium]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0031941 [filamentous actin]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050885 [neuromuscular process controlling balance]
GO:0050905 [neuromuscular process]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051932 [synaptic transmission, GABAergic]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
192 aa
21.4 kDa
No 0
RAC3-002
ENSP00000463590
ENST00000580965
J3QLK0 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
136 aa
15.4 kDa
No 0
RAC3-003
ENSP00000462421
ENST00000584341
J3KSC4 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
130 aa
14.8 kDa
No 0

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