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RAC3

GENERAL INFORMATION

Gene name

 RAC3

Gene description

 Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047820
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 RAC3

Synonyms

Description

 Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 82031624 - 82034204

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169750 (version 83.38)

Entrez gene

 5881

UniProt

 P60763 (UniProt - Evidence at protein level)

neXtProt

 NX_P60763

Antibodypedia

 RAC3 antibodies

PROTEIN BROWSER
RAC3-001
RAC3-002
RAC3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAC3-001
ENSP00000304283
ENST00000306897
P60763 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0012505 [endomembrane system]
GO:0014041 [regulation of neuron maturation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0021894 [cerebral cortex GABAergic interneuron development]
GO:0022604 [regulation of cell morphogenesis]
GO:0030027 [lamellipodium]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0031941 [filamentous actin]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050885 [neuromuscular process controlling balance]
GO:0050905 [neuromuscular process]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051932 [synaptic transmission, GABAergic]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 192 aa
21.4 kDa 		No 0
RAC3-002
ENSP00000463590
ENST00000580965
J3QLK0 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 136 aa
15.4 kDa 		No 0
RAC3-003
ENSP00000462421
ENST00000584341
J3KSC4 [Direct mapping]
Ras-related C3 botulinum toxin substrate 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 130 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.