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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Detectable

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NLGN1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NLGN1

Gene description

Neuroligin 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in brain, several glandular cells

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA006680
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
N/A
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

NLGN1 (HGNC Symbol)

Synonyms

KIAA1070

Description

Neuroligin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.31

Chromosome location (bp)

173396284 - 174286644

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169760 (version 83.38)

Entrez gene

22871

UniProt

Q8N2Q7 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N2Q7

Antibodypedia

NLGN1 antibodies

PROTEIN BROWSER

NLGN1-001
NLGN1-002
NLGN1-003
NLGN1-005
NLGN1-007
NLGN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NLGN1-001
ENSP00000392500
ENST00000457714
Q8N2Q7 [Direct mapping]
Neuroligin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002087 [regulation of respiratory gaseous exchange by neurological system process]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006605 [protein targeting]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007158 [neuron cell-cell adhesion]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010841 [positive regulation of circadian sleep/wake cycle, wakefulness]
GO:0014069 [postsynaptic density]
GO:0016080 [synaptic vesicle targeting]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0023041 [neuronal signal transduction]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0031175 [neuron projection development]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032433 [filopodium tip]
GO:0035418 [protein localization to synapse]
GO:0042043 [neurexin family protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045664 [regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0048511 [rhythmic process]
GO:0048789 [cytoskeletal matrix organization at active zone]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0051260 [protein homooligomerization]
GO:0051290 [protein heterotetramerization]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051965 [positive regulation of synapse assembly]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060076 [excitatory synapse]
GO:0060291 [long-term synaptic potentiation]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0072553 [terminal button organization]
GO:0097091 [synaptic vesicle clustering]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097114 [NMDA glutamate receptor clustering]
GO:0097115 [neurexin clustering involved in presynaptic membrane assembly]
GO:0097119 [postsynaptic density protein 95 clustering]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
GO:1900029 [positive regulation of ruffle assembly]
GO:1900244 [positive regulation of synaptic vesicle endocytosis]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000302 [positive regulation of synaptic vesicle exocytosis]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000809 [positive regulation of synaptic vesicle clustering]
Show all
823 aa
92 kDa
No 1
NLGN1-002
ENSP00000354541
ENST00000361589
Q8N2Q7 [Direct mapping]
Neuroligin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006605 [protein targeting]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007158 [neuron cell-cell adhesion]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0009986 [cell surface]
GO:0010841 [positive regulation of circadian sleep/wake cycle, wakefulness]
GO:0014069 [postsynaptic density]
GO:0016080 [synaptic vesicle targeting]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0023041 [neuronal signal transduction]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0031175 [neuron projection development]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032433 [filopodium tip]
GO:0035418 [protein localization to synapse]
GO:0042043 [neurexin family protein binding]
GO:0043197 [dendritic spine]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045664 [regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048511 [rhythmic process]
GO:0048789 [cytoskeletal matrix organization at active zone]
GO:0050804 [modulation of synaptic transmission]
GO:0050839 [cell adhesion molecule binding]
GO:0051260 [protein homooligomerization]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051965 [positive regulation of synapse assembly]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060076 [excitatory synapse]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061002 [negative regulation of dendritic spine morphogenesis]
GO:0072553 [terminal button organization]
GO:0097091 [synaptic vesicle clustering]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097114 [NMDA glutamate receptor clustering]
GO:0097115 [neurexin clustering involved in presynaptic membrane assembly]
GO:0097119 [postsynaptic density protein 95 clustering]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
GO:1900029 [positive regulation of ruffle assembly]
GO:1900244 [positive regulation of synaptic vesicle endocytosis]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000302 [positive regulation of synaptic vesicle exocytosis]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
823 aa
92 kDa
No 1
NLGN1-003
ENSP00000410374
ENST00000415045
C9J4D3 [Direct mapping]
Neuroligin-1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0042043 [neurexin family protein binding]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0060076 [excitatory synapse]
Show all
367 aa
39.9 kDa
No 0
NLGN1-005
ENSP00000407255
ENST00000423427
C9JWG7 [Direct mapping]
Neuroligin-1
Show all
Predicted intracellular proteins
Show all
13 aa
1.6 kDa
No 0
NLGN1-007
ENSP00000401843
ENST00000413821
Predicted intracellular proteins
Show all
10 aa
1.2 kDa
No 0
NLGN1-201
ENSP00000385750
ENST00000401917
J3KQ19 [Direct mapping]
Neuroligin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0042043 [neurexin family protein binding]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0060076 [excitatory synapse]
Show all
608 aa
68.3 kDa
No 1

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The Human Protein Atlas project is funded
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