Expression of ITGAM in cancer - Summary - The Human Protein Atlas

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ITGAM

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ITGAM
Gene description	Integrin, alpha M (complement component 3 receptor 3 subunit)
Protein class	Cancer-related genes CD markers Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, NB-4, U-937)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA002274 , CAB025091 , CAB072870
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002274	CAB025091	CAB072870

GENE INFORMATION
Gene name	ITGAM (HGNC Symbol)
Synonyms	CD11B, CR3A, MAC-1
Description	Integrin, alpha M (complement component 3 receptor 3 subunit) (HGNC Symbol)
Entrez gene summary	This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31259990 - 31332892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169896 (version 83.38)
Entrez gene	3684
UniProt	P11215 (UniProt - Evidence at protein level)
neXtProt	NX_P11215
Antibodypedia	ITGAM antibodies

PROTEIN BROWSER

ITGAM-001	ITGAM-002	ITGAM-003	ITGAM-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGAM-001 ENSP00000441691 ENST00000544665	P11215 [Direct mapping] Integrin alpha-M Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0009986 [cell surface] GO:0010668 [ectodermal cell differentiation] GO:0030198 [extracellular matrix organization] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	1153 aa 127.3 kDa	Yes	1
ITGAM-002 ENSP00000287497 ENST00000287497	P11215 [Direct mapping] Integrin alpha-M Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0009986 [cell surface] GO:0010668 [ectodermal cell differentiation] GO:0030198 [extracellular matrix organization] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	1152 aa 127.2 kDa	Yes	1
ITGAM-003 ENSP00000454568 ENST00000567031	H3BMV4 [Direct mapping] Integrin alpha-M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 18.1 kDa	No	0
ITGAM-008 ENSP00000461850 ENST00000565142	I3NI33 [Direct mapping] Integrin alpha-M Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 12.3 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.