Cell atlas - OTUD7A - The Human Protein Atlas

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OTUD7A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	OTUD7A
Gene description	OTU deubiquitinase 7A
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044554
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & cytosol.

Main location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044554	A-431	Nucleoli
	HPA044554	A-431	Cytosol
	HPA044554	U-2 OS	Nucleoli
	HPA044554	U-2 OS	Cytosol
	HPA044554	U-251 MG	Nucleoli
	HPA044554	U-251 MG	Cytosol

GENE INFORMATION
Gene name	OTUD7A (HGNC Symbol)
Synonyms	C15orf16, CEZANNE2, OTUD7
Description	OTU deubiquitinase 7A (HGNC Symbol)
Entrez gene summary	Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Chromosome	15
Cytoband	q13.3
Chromosome location (bp)	31475398 - 31870789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169918 (version 83.38)
Entrez gene	161725
UniProt	Q8TE49 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE49
Antibodypedia	OTUD7A antibodies

PROTEIN BROWSER

OTUD7A-001	OTUD7A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTUD7A-001 ENSP00000305926 ENST00000307050	Q8TE49 [Direct mapping] OTU domain-containing protein 7A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0004843 [ubiquitin-specific protease activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0035871 [protein K11-linked deubiquitination] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088 [regulation of innate immune response] GO:0050727 [regulation of inflammatory response] GO:0070530 [K63-linked polyubiquitin binding] GO:0070536 [protein K63-linked deubiquitination] GO:0071108 [protein K48-linked deubiquitination] GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	926 aa 100.7 kDa	No	0
OTUD7A-004 ENSP00000453883 ENST00000560598	H0YN66 [Direct mapping] OTU domain-containing protein 7A Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Show all	GO:0005515 [protein binding] Show all	110 aa 12.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.