Expression of OTUD7A in cancer - Summary - The Human Protein Atlas

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OTUD7A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OTUD7A
Gene description	OTU deubiquitinase 7A
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044554
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044554

GENE INFORMATION
Gene name	OTUD7A (HGNC Symbol)
Synonyms	C15orf16, CEZANNE2, OTUD7
Description	OTU deubiquitinase 7A (HGNC Symbol)
Entrez gene summary	Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Chromosome	15
Cytoband	q13.3
Chromosome location (bp)	31475398 - 31870789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169918 (version 83.38)
Entrez gene	161725
UniProt	Q8TE49 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE49
Antibodypedia	OTUD7A antibodies

PROTEIN BROWSER

OTUD7A-001	OTUD7A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTUD7A-001 ENSP00000305926 ENST00000307050	Q8TE49 [Direct mapping] OTU domain-containing protein 7A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0004843 [ubiquitin-specific protease activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0035871 [protein K11-linked deubiquitination] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088 [regulation of innate immune response] GO:0050727 [regulation of inflammatory response] GO:0070530 [K63-linked polyubiquitin binding] GO:0070536 [protein K63-linked deubiquitination] GO:0071108 [protein K48-linked deubiquitination] GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	926 aa 100.7 kDa	No	0
OTUD7A-004 ENSP00000453883 ENST00000560598	H0YN66 [Direct mapping] OTU domain-containing protein 7A Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Show all	GO:0005515 [protein binding] Show all	110 aa 12.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.