Cell atlas - BRD3 - The Human Protein Atlas

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BRD3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BRD3
Gene description	Bromodomain containing 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Mouse	Localized to the Nuclear bodies in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051830
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051830	HeLa	Nuclear bodies
	HPA051830	MCF7	Nuclear bodies
	HPA051830	U-2 OS	Nuclear bodies

MOUSE CELLS

Main location

Nuclear bodies

Mouse gene

ENSMUSG00000026918 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051830	NIH 3T3	Nuclear bodies

GENE INFORMATION
Gene name	BRD3 (HGNC Symbol)
Synonyms	KIAA0043, ORFX, RING3L
Description	Bromodomain containing 3 (HGNC Symbol)
Entrez gene summary	This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	134030305 - 134068535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169925 (version 83.38)
Entrez gene	8019
UniProt	Q15059 (UniProt - Evidence at protein level)
neXtProt	NX_Q15059
Antibodypedia	BRD3 antibodies

PROTEIN BROWSER

BRD3-001	BRD3-002	BRD3-004	BRD3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRD3-001 ENSP00000305918 ENST00000303407	Q15059 [Direct mapping] Bromodomain-containing protein 3 A0A024R8H6 [Target identity:100%; Query identity:100%] Bromodomain containing 3, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016568 [chromatin modification] GO:0070577 [lysine-acetylated histone binding] Show all	726 aa 79.5 kDa	No	0
BRD3-002 ENSP00000360900 ENST00000371834	Q15059 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016568 [chromatin modification] GO:0070577 [lysine-acetylated histone binding] Show all	556 aa 60.9 kDa	No	0
BRD3-004 ENSP00000360908 ENST00000371842	A9J571 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	74 aa 8.2 kDa	No	0
BRD3-005 ENSP00000406749 ENST00000433041	A9J575 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		20 aa 1.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.