Expression of BRD3 in cancer - Summary - The Human Protein Atlas

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BRD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BRD3
Gene description	Bromodomain containing 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, including dendritic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051830
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051830

GENE INFORMATION
Gene name	BRD3 (HGNC Symbol)
Synonyms	KIAA0043, ORFX, RING3L
Description	Bromodomain containing 3 (HGNC Symbol)
Entrez gene summary	This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	134030305 - 134068535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169925 (version 83.38)
Entrez gene	8019
UniProt	Q15059 (UniProt - Evidence at protein level)
neXtProt	NX_Q15059
Antibodypedia	BRD3 antibodies

PROTEIN BROWSER

BRD3-001	BRD3-002	BRD3-004	BRD3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRD3-001 ENSP00000305918 ENST00000303407	Q15059 [Direct mapping] Bromodomain-containing protein 3 A0A024R8H6 [Target identity:100%; Query identity:100%] Bromodomain containing 3, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016568 [chromatin modification] GO:0070577 [lysine-acetylated histone binding] Show all	726 aa 79.5 kDa	No	0
BRD3-002 ENSP00000360900 ENST00000371834	Q15059 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016568 [chromatin modification] GO:0070577 [lysine-acetylated histone binding] Show all	556 aa 60.9 kDa	No	0
BRD3-004 ENSP00000360908 ENST00000371842	A9J571 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	74 aa 8.2 kDa	No	0
BRD3-005 ENSP00000406749 ENST00000433041	A9J575 [Direct mapping] Bromodomain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		20 aa 1.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.