Expression of FRMPD4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FRMPD4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FRMPD4
Gene description	FERM and PDZ domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (LHCN-M2, U-2197, U-266/70)
HPA (normal tissue):	Group enriched (cerebral cortex, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in CNS and parathyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA035580
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035580

GENE INFORMATION
Gene name	FRMPD4 (HGNC Symbol)
Synonyms	KIAA0316, PDZD10, PDZK10
Description	FERM and PDZ domain containing 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	12138466 - 12724523
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169933 (version 83.38)
Entrez gene	9758
UniProt	Q14CM0 (UniProt - Evidence at protein level)
neXtProt	NX_Q14CM0
Antibodypedia	FRMPD4 antibodies

PROTEIN BROWSER

FRMPD4-001	FRMPD4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRMPD4-001 ENSP00000370057 ENST00000380682	Q14CM0 [Direct mapping] FERM and PDZ domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005856 [cytoskeleton] GO:0043197 [dendritic spine] GO:0051835 [positive regulation of synapse structural plasticity] Show all	1322 aa 144.4 kDa	No	0
FRMPD4-201 ENSP00000482182 ENST00000616992	A0A087WYX8 [Direct mapping] FERM and PDZ domain-containing protein 4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] Show all	1282 aa 140 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.